PKD1 Protein (AA 177-359) (His tag)
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- 抗原 See all PKD1 蛋白
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 177-359
- 宿主
- 人
- 资源
- 大肠杆菌（E. Coli）
- 标记
- This PKD1 protein is labelled with His tag.
- 序列
- Gly 177-Leu 359
- 产品特性
- A DNA sequence encoding the Human PKD1 protein (P98161) (Gly 177-Leu 359) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
- 别名
- PKD1 (PKD1 产品)
- 别名
- PBP Protein, Pc-1 Protein, TRPP1 Protein, PC1 Protein, mFLJ00285 Protein, polycystin 1, transient receptor potential channel interacting Protein, polycystin 1, transient receptor poteintial channel interacting Protein, polycystin-1 Protein, PKD1 Protein, Pkd1 Protein, LOC749291 Protein
- 背景
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Abbreviation: PKD1
Target Synonym: Polycystin-1,PKD1,Autosomal dominant polycystic kidney disease 1 protein
Background: Polycystin-1 (also PKD1) is a 500-550 kDa member of the polycystin family of proteins. It is expressed in renal tubule primary cilia, and the membrane region that forms adherens junctions. Polycystin-1 binds to polycystin-2, promoting its insertion into the cell membrane, and regulating its calcium channel activity. In conjunction with polycystin-2, it detects fluid flow and converts this information into calcium signals. It also exists in the ER, where it negatively modulates polycystin-2 mediated calcium release. Mature human polycystin-1 is a 4280 amino acid (aa), 11 transmembrane glycoprotein.
- 分子量
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Calculated MW: 20.02 kDa
Observed MW: 22 kDa
- UniProt
- P98161
- 途径
- Myometrial Relaxation and Contraction, Maintenance of Protein Location
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