RAC2 Protein (AA 1-189) (His tag)
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- 抗原 See all RAC2 蛋白
- RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-189
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This RAC2 protein is labelled with His tag.
- 序列
- Met 1-Cys 189
- 产品特性
- A DNA sequence encoding the Human Rac2 protein (P15153) (Met 1-Cys 189) was expressed with a N-His&C-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RAC2 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) (RAC2))
- 别名
- Rac2 (RAC2 产品)
- 别名
- rac2 Protein, AI323801 Protein, AI452260 Protein, EN-7 Protein, Gx Protein, HSPC022 Protein, p21-Rac2 Protein, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) Protein, RAS-related C3 botulinum substrate 2 Protein, Rac family small GTPase 2 Protein, rac2 Protein, Rac2 Protein, RAC2 Protein
- 背景
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Abbreviation: Rac2
Target Synonym: EN-7;Gx;HSPC022;p21-Rac2
Background: Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.
- 分子量
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Calculated MW: 20.68 kDa
Observed MW: 25 kDa
- UniProt
- P15153
- 途径
- RTK signaling, VEGF Signaling
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