PTPN11 Protein (AA 2-521) (His tag)
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- 抗原 See all PTPN11 蛋白
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-521
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PTPN11 protein is labelled with His tag.
- 序列
- Thr 2-Ala 521
- 产品特性
- A DNA sequence encoding the Human PTPN11 protein (Q06124) (Thr 2-Ala 521) was expressed with N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PTPN11 蛋白
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Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) protein (GST tag)
PTPN11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (Active) protein (His tag)PTPN11 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) protein (His tag)PTPN11 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) protein (Myc-DYKDDDDK Tag)PTPN11 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- 别名
- PTPN11 (PTPN11 产品)
- 别名
- BPTP3 Protein, CFC Protein, NS1 Protein, PTP-1D Protein, PTP2C Protein, SH-PTP2 Protein, SH-PTP3 Protein, SHP2 Protein, 2700084A17Rik Protein, AW536184 Protein, PTP1D Protein, SAP-2 Protein, SHP-2 Protein, Shp2 Protein, Syp Protein, SYP Protein, bptp3 Protein, cfc Protein, ns1 Protein, ptp-2 Protein, ptp2c Protein, ptpn11 Protein, ptpn11-a Protein, ptpn11-b Protein, shp-2 Protein, shp2 Protein, fa14b09 Protein, wu:fa14b09 Protein, wu:fi24f03 Protein, zgc:55388 Protein, zgc:63553 Protein, protein tyrosine phosphatase, non-receptor type 11 Protein, protein tyrosine phosphatase, non-receptor type 11 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 11, a Protein, protein tyrosine phosphatase, non-receptor type 11, b Protein, PTPN11 Protein, Ptpn11 Protein, ptpn11.S Protein, ptpn11a Protein, ptpn11b Protein
- 物质类
- Viral Protein
- 背景
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Abbreviation: PTPN11
Target Synonym: BPTP3,CFC,JMML,METCDS,NS1,PTN11,PTP-1D,PTP2C,SAP2,SH-PTP2,SH-PTP3,SHP2,SHPTP2,SHPTP3,Syp
Background: SHP-2 (PTPN11) is a ubiquitously expressed, nonreceptor protein tyrosine phosphatase (PTP). It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens, and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. In addition to its role in Gab1-mediated Erk activation, SHP-2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 at p85 binding sites. SHP-2 becomes phosphorylated at Tyr542 and Tyr580 in its carboxy terminus in response to growth factor receptor activation. These phosphorylation events are thought to relieve basal inhibition and stimulate SHP-2 tyrosine phosphatase activity. Mutations in the corresponding gene result in a pair of clinically similar disorders (Noonan syndrome and LEOPARD syndrome) that may result from abnormal MAPK regulation.
- 分子量
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Calculated MW: 57.09 kDa
Observed MW: 60 kDa
- UniProt
- Q06124
- 途径
- JAK/STAT Signaling, RTK signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect
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