CASR Protein (AA 863-1078) (His tag)
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- 抗原 See all CASR 蛋白
- CASR (Calcium-Sensing Receptor (CASR))
- 蛋白类型
- Recombinant
- 产品特性
- AA 863-1078
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CASR protein is labelled with His tag.
- 序列
- Lys 863-Ser 1078
- 产品特性
- A DNA sequence encoding the Human CaSR protein (P41180) (Lys 863-Ser 1078) was expressed with N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CASR 蛋白
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Calcium-Sensing Receptor (CASR) (AA 21-120) protein (GST tag)
CASR 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, AA, ELISA
Calcium-Sensing Receptor (CASR) (AA 21-130) protein (GST tag)CASR 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, AA, ELISA
Calcium-Sensing Receptor (CASR) (AA 20-612), (Extracellular) protein (GST tag)CASR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Calcium-Sensing Receptor (CASR) (AA 20-612) protein (His tag)CASR 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- CASR (Calcium-Sensing Receptor (CASR))
- 别名
- CaSR (CASR 产品)
- 别名
- CAR Protein, EIG8 Protein, FHH Protein, FIH Protein, GPRC2A Protein, HHC Protein, HHC1 Protein, HYPOC1 Protein, NSHPT Protein, PCAR1 Protein, CaR Protein, Gprc2a Protein, gprc2a Protein, xV2R F-1 Protein, CASR Protein, calcium sensing receptor Protein, calcium-sensing receptor Protein, calcium-sensing receptor L homeolog Protein, CASR Protein, Casr Protein, casr.L Protein
- 背景
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Abbreviation: CaSR
Target Synonym: Ca sensing receptor,Ca2+ sensing receptor 1,CAR,EIG8,Extracellular calcium sensing receptor,FHH,FIH,GPRC2A,HHC1,NSHPT,PCAR 1,PCaR1
Background: CaSR, the extracellular Calcium-Sensing Receptor, is a widely expressed G-protein coupled receptor (GPCR) involved in calcium homeostasis. CaSR operates as a sensor in parathyroid and kidney, and alterations in its activity have been shown to cause thyroid disease in humans. Activation of the receptor in response to extracellular calcium or other ligands causes activation of phospholipase C (PLC), release of IP3 and release of calcium from intracellular stores. Proinflammatory cytokines IL-1β and TNF-α increase CaSR gene expression in human thyroid and kidney cells through activation of the NF-κB pathway, and this pathway may be involved in hypocalcemia often seen in critically ill patients. Elevated calcium concentration and CaSR expression have been linked to proliferation and metastasis of skeletal metastatic prostate cancer cell lines. In intestinal epithelial cells, CaSR is involved in regulation of cyclic nucleotide metabolism and the fluid secretion that results in life-threatening fluid loss in response to intestinal pathogens. The interaction of CaSR with the actin-binding protein filamin may provide scaffolding for the organization of signaling pathways converging on the cytoskeleton, including CaSR-mediated MAPK pathway activation.
- 分子量
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Calculated MW: 23.65 kDa
Observed MW: 35 kDa
- UniProt
- P41180
- 途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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