PKM2 Protein (AA 2-531) (His tag)
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- 抗原 See all PKM2 蛋白
- PKM2 (Pyruvate Kinase M2 (PKM2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-531
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PKM2 protein is labelled with His tag.
- 序列
- Ser 2-Pro 531
- 产品特性
- A DNA sequence encoding the Human PKM2 protein (P14618) (Ser 2-Pro 531) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PKM2 蛋白
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Pyruvate Kinase M2 (PKM2) (AA 436-531) protein (GST tag)
PKM2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Pyruvate Kinase M2 (PKM2) (AA 1-531) protein (GST tag)PKM2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Pyruvate Kinase M2 (PKM2) (AA 1-531) protein (His tag)PKM2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Pyruvate Kinase M2 (PKM2) (AA 1-531) protein (His tag)PKM2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Pyruvate Kinase M2 (PKM2) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)PKM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- PKM2 (Pyruvate Kinase M2 (PKM2))
- 别名
- PKM2 (PKM2 产品)
- 别名
- CTHBP Protein, OIP3 Protein, PK3 Protein, PKM2 Protein, TCB Protein, THBP1 Protein, AA414905 Protein, AL024370 Protein, AL024424 Protein, Pk-2 Protein, Pk-3 Protein, Pk3 Protein, Pkm2 Protein, PKM12 Protein, PKM Protein, pyruvate kinase M1/2 Protein, pyruvate kinase, muscle Protein, PKM Protein, Pkm Protein
- 背景
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Abbreviation: PKM2
Target Synonym: CTHBP,HEL-S-30,OIP3,PK3,PKM2,TCB,THBP1
Background: Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an isoenzyme of the glycolytic enzyme pyruvate kinase. Pyruvate kinase isozymes M2 / PKM2 is a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. PKM2 has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. PKM2 has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. PKM2 functions as a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. PKM2 may stimulates POU5F1-mediated transcriptional activation. This protein Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms of PKM2 contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
- 分子量
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Calculated MW: 58.19 kDa
Observed MW: 59 kDa
- UniProt
- P14618
- 途径
- Warburg Effect
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