BMP7 Protein (AA 293-431) (His tag)
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- 抗原 See all BMP7 蛋白
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
- 蛋白类型
- Recombinant
- 产品特性
- AA 293-431
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This BMP7 protein is labelled with His tag.
- 序列
- Ser 293-His 431
- 产品特性
- A DNA sequence encoding the Human BMP-7 protein (P18075) (Ser293-His431) was expressed with a N-His .
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product BMP7 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
- 别名
- BMP-7 (BMP7 产品)
- 别名
- bmp-7 Protein, bmp7 Protein, op-1 Protein, BMP7 Protein, zgc:153025 Protein, OP-1 Protein, OP1 Protein, BMP-7 Protein, fb83f09 Protein, wu:fb83f09 Protein, bone morphogenetic protein 7 Protein, bone morphogenetic protein 7, gene 1 L homeolog Protein, bone morphogenetic protein 7b Protein, bone morphogenetic protein 7, gene 2 L homeolog Protein, bone morphogenetic protein 7a Protein, BMP7 Protein, bmp7.1.L Protein, LOC100136282 Protein, bmp7b Protein, Bmp7 Protein, LOC100008826 Protein, bmp7.2.L Protein, bmp7a Protein
- 背景
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Abbreviation: BMP-7
Target Synonym: Bone morphogenetic protein 7,BMP-7,Osteogenic protein 1,OP-1,Eptotermin alfa
Background: BMP-7 (Bone morphogenetic protein 7), also known as osteogenic protein 1 (OP-1), is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys and bladder. BMP-7 may be involved in bone homeostasis. Osteogenic protein 1 plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. The expression of BMP-7 causes ventral phenotypes while its complete inhibition creates a dorsal phenotype. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.
- 分子量
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Calculated MW: 15.18 kDa
Observed MW: 15 kDa
- UniProt
- P18075
- 途径
- Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
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