CPB2 Protein (AA 138-386) (His tag)
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- 抗原 See all CPB2 蛋白
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 138-386
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This CPB2 protein is labelled with His tag.
- 序列
- Glu 138-Val 386
- 产品特性
- A DNA sequence encoding the Human TAFI protein (Q96IY4) (Glu138-Val386) was expressed with a N-His .
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CPB2 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- 别名
- TAFI (CPB2 产品)
- 别名
- CPU Protein, PCPB Protein, TAFI Protein, 1110032P04Rik Protein, 4930405E17Rik Protein, AI255929 Protein, CPR Protein, Cpu Protein, pCPB Protein, zgc:112493 Protein, carboxypeptidase B2 Protein, carboxypeptidase B2 (plasma) Protein, CPB2 Protein, Cpb2 Protein, cpb2 Protein
- 背景
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Abbreviation: TAFI
Target Synonym: Carboxypeptidase B2,Carboxypeptidase U,CPU,Plasma Carboxypeptidase B,pCPB,Thrombin-Activable Fibrinolysis Inhibitor,TAFI,CPB2
Background: Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CPB2 exhibits carboxypeptidase activity when it is activated by proteolysis at residue Arg92 of the thrombin/thrombomodulin complex. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
- 分子量
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Calculated MW: 27.28 kDa
Observed MW: 32 kDa
- UniProt
- Q96IY4
- 途径
- Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
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