NADPH Oxidase 4 Protein (NOX4) (AA 220-392) (His tag)
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- 抗原 See all NADPH Oxidase 4 (NOX4) 蛋白
- NADPH Oxidase 4 (NOX4)
- 蛋白类型
- Recombinant
- 产品特性
- AA 220-392
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This NADPH Oxidase 4 protein is labelled with His tag.
- 序列
- Asp 220-Asp 392
- 产品特性
- A DNA sequence encoding the Human NOX4 protein (Q9NPH5) (Asp 220-Asp 392) was expressed with a N-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product NOX4 蛋白
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NADPH Oxidase 4 (NOX4) (AA 479-578) protein (GST tag)
NOX4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- NADPH Oxidase 4 (NOX4)
- 别名
- NOX4 (NOX4 产品)
- 别名
- KOX Protein, KOX-1 Protein, RENOX Protein, AI648021 Protein, nox4 Protein, NOX4 Protein, NADPH oxidase 4 Protein, NOX4 Protein, Nox4 Protein, nox4 Protein, PTRG_09562 Protein
- 背景
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Abbreviation: NOX4
Target Synonym: KOX 1,KOX,Kox-1,KOX1,NADPH,NADPH oxidase Nox4,NOX4,Renal NAD(P)H oxidase,Renal NAD(P)H-oxidase,RENOX
Background: NADPH Oxidase 4/NOX4, also known as Renal NADPH Oxidase/RENOX and Kidney Oxidase 1/KOX1, is a 66 to 75 kDa member of the NOX family of NADPH oxidases. NOX family members are a major source of reactive oxygen species (ROS), including hydrogen peroxide and superoxide, and are critical mediators of redox signaling. NOX4 is strongly expressed in the kidney, especially in the proximal convoluted tubule cells of the renal cortex, and may function as an oxygen sensor that regulates the synthesis of erythropoietin. Expression is also high in endothelial cells, and because aortas from deficient mice exhibit increased inflammation, hypertrophy and endothelial dysfunction, NOX4 may function to protect the vasculature during ischemic or inflammatory stress. Human NOX4 is 578 amino acids (aa) in length, with several additional smaller isoforms identified. Over aa 450-578, human NOX4 has 92 % sequence identity with mouse NOX4, and 91 % identity with rat NOX4.
- 分子量
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Calculated MW: 18.92 kDa
Observed MW: 18 kDa
- UniProt
- Q9NPH5
- 途径
- Carbohydrate Homeostasis, Smooth Muscle Cell Migration
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