ABL1 Protein (AA 845-993) (His tag)
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- 抗原 See all ABL1 蛋白
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 845-993
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This ABL1 protein is labelled with His tag.
- 序列
- Pro 845-Ala 993
- 产品特性
- A DNA sequence encoding the Human ABL1/c-Abl protein (P00519) (Pro 845-Ala 993) was expressed with a N-His&C-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ABL1 蛋白
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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 931-1030) protein (GST tag)
ABL1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, AA, AP, WB
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Active) protein (GST tag)ABL1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 75 % as determined by reducing SDS-PAGE. Active
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 4-194), (partial) protein (GST tag)ABL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 4-194), (partial) protein (GST tag)ABL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- 别名
- ABL1 (ABL1 产品)
- 别名
- ABL Protein, JTK7 Protein, bcr/abl Protein, c-ABL Protein, p150 Protein, v-abl Protein, AI325092 Protein, Abl Protein, E430008G22Rik Protein, c-Abl Protein, ABL proto-oncogene 1, non-receptor tyrosine kinase Protein, c-abl oncogene 1, non-receptor tyrosine kinase Protein, Tyrosine-protein kinase abl-1 Protein, ABL1 Protein, Abl1 Protein, abl-1 Protein, abl1 Protein
- 背景
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Abbreviation: ABL1,c-Abl
Target Synonym: ABL,bcr/abl,c-ABL,c-ABL1,JTK7,p150,v-abl
Background: c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.
- 分子量
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Calculated MW: 16.28 kDa
Observed MW: 25 kDa
- UniProt
- P00519
- 途径
- Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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