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CXCR3 Protein-VLP

CXCR3 宿主: 人 宿主: HEK-293 Cells VLP
产品编号 ABIN7488804
发货至: 中国
  • 抗原 See all CXCR3 蛋白
    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
    蛋白类型
    VLP
    宿主
    • 9
    • 3
    • 2
    资源
    • 4
    • 4
    • 3
    • 2
    HEK-293 Cells
    原理
    Human CXCR3 Full Length Protein (VLP)
    序列
    Val 2 - Leu 368
    产品特性
    Human CXCR3 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 368 (Accession # P49682-1).
    内毒素水平
    1.0 EU per μg
    Top Product
    Discover our top product CXCR3 蛋白
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, Arginine, pH 7.4
    储存条件
    -80 °C
    储存方法
    -70°C
  • 抗原
    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
    别名
    CXCR3 (CXCR3 产品)
    别名
    CD182 Protein, CD183 Protein, CKR-L2 Protein, CMKAR3 Protein, GPR9 Protein, IP10-R Protein, Mig-R Protein, MigR Protein, Cd183 Protein, Cmkar3 Protein, CXCR3 Protein, cxcr3 Protein, Gpr9 Protein, CXC-R3 Protein, CXCR-3 Protein, zgc:92301 Protein, sb:eu378 Protein, C-X-C motif chemokine receptor 3 Protein, chemokine (C-X-C motif) receptor 3 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 2 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 1 Protein, CXCR3 Protein, Cxcr3 Protein, cxcr3 Protein, cxcr3.2 Protein, cxcr3.1 Protein
    背景
    Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
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