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CXCR3 Protein-VLP

This VLP CXCR3 protein is expressed in HEK-293 Cells.
产品编号 ABIN7488804
发货至: 中国

Quick Overview for CXCR3 Protein-VLP (ABIN7488804)

抗原

See all CXCR3 蛋白
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

蛋白类型

VLP

宿主

  • 12
  • 4
  • 2

资源

  • 6
  • 5
  • 4
  • 2
HEK-293 Cells
  • 原理

    Human CXCR3 Full Length Protein (VLP)

    序列

    Val 2 - Leu 368

    产品特性

    Human CXCR3 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 368 (Accession # P49682-1).

    内毒素水平

    1.0 EU per μg
  • 想要此Protein的其他选项吗?

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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 136,947.45 ¥
    表达系统 Cell-free protein synthesis (CFPS)
    Conjugate Strep Tag
    Origin Human
    价格从 172,528.32 ¥

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  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS, Arginine, pH 7.4

    储存条件

    -80 °C

    储存方法

    -70°C
  • 抗原

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    别名

    CXCR3

    背景

    Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
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