-
- 抗原 See all CMKLR1 蛋白
- CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
- 蛋白类型
- Synthetic Nanodisc
-
宿主
- 人
-
资源
- HEK-293 Cells
- 原理
- Human CMKLR1 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
-
Chemokine-Like Receptor 1 (CMKLR1) (AA 1-371) protein (GST tag)
CMKLR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
-
- 说明
-
Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
-
- 抗原
- CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
- 别名
- CMKLR1 (CMKLR1 产品)
- 别名
- CHEMERINR Protein, ChemR23 Protein, DEZ Protein, RVER1 Protein, Gpcr27 Protein, mcmklr1 Protein, si:ch211-240b21.3 Protein, CMLKR1 Protein, Cmklr-1 Protein, GPCR Protein, chemerin chemokine-like receptor 1 Protein, chemokine-like receptor 1 Protein, CMKLR1 Protein, Cmklr1 Protein, cmklr1 Protein
- 背景
- Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
- 分子量
- The human full length CMKLR1 protein has a MW of 42.3 kDa
- UniProt
- Q99788
-
You are here:
