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Prostaglandin D2 Receptor 2 (PTGDR2) 蛋白

PTGDR2 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
产品编号 ABIN7491717
发货至: 中国
  • 抗原 See all Prostaglandin D2 Receptor 2 (PTGDR2) products
    Prostaglandin D2 Receptor 2 (PTGDR2)
    蛋白类型
    Synthetic Nanodisc
    宿主
    • 1
    • 1
    资源
    • 2
    HEK-293 Cells
    原理
    Human PTGDR2 full length protein-synthetic nanodisc
    产品特性
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • 说明

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    Prostaglandin D2 Receptor 2 (PTGDR2)
    别名
    PTGDR2 (PTGDR2 产品)
    别名
    CD294 Protein, CRTH2 Protein, DL1R Protein, DP2 Protein, GPR44 Protein, Crth2 Protein, Grp45 Protein, Ptgdr2 Protein, Gpr44 Protein, prostaglandin D2 receptor 2 Protein, PTGDR2 Protein, Ptgdr2 Protein
    背景
    The protein is a G-protein-coupled receptor that is preferentially expressed in CD4 effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.
    分子量
    The human full length PTGDR2 protein has a MW of 43.3 kDa
    UniProt
    Q9Y5Y4
    途径
    Regulation of G-Protein Coupled Receptor Protein Signaling
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