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- 抗原 See all CLPTM1 蛋白
- CLPTM1 (Cleft Lip and Palate Associated Transmembrane Protein 1 (CLPTM1))
- 蛋白类型
- Synthetic Nanodisc
- 宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human CLPTM1 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Cleft Lip and Palate Associated Transmembrane Protein 1 (CLPTM1) (AA 151-251) protein (GST tag)
CLPTM1 宿主: 人 宿主: 小麦胚 Recombinant AA, AP, ELISA, WB
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- CLPTM1 (Cleft Lip and Palate Associated Transmembrane Protein 1 (CLPTM1))
- 别名
- CLPTM1 (CLPTM1 产品)
- 别名
- CLPTM1 Protein, cb102 Protein, sb:cb102 Protein, zgc:100803 Protein, HS9 Protein, N14 Protein, CLPTM1, transmembrane protein Protein, cleft lip and palate associated transmembrane protein 1 Protein, CLPTM1 Protein, clptm1 Protein, Bm1_06285 Protein, PTRG_03625 Protein, Clptm1 Protein
- 背景
- Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one.
- 分子量
- The human full length CLPTM1 protein has a MW of 76.1 kDa
- UniProt
- O96005
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