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- 抗原 See all LGR5 蛋白
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human LGR5 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product LGR5 蛋白
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Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-543) protein (Fc Tag)
LGR5 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-561) (Active) protein (His tag)LGR5 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-561) protein (His tag)LGR5 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
- 别名
- LGR5 (LGR5 产品)
- 别名
- lgr5-a Protein, lgr5a Protein, FEX Protein, Gpr49 Protein, GPR49 Protein, GPR67 Protein, GRP49 Protein, HG38 Protein, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog Protein, leucine rich repeat containing G protein coupled receptor 5 Protein, leucine rich repeat containing G protein-coupled receptor 5 Protein, lgr5.L Protein, Lgr5 Protein, LGR5 Protein
- 背景
- The protein is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
- 分子量
- The human full length LGR5 protein has a MW of 100.0 kDa
- UniProt
- O75473
- 途径
- WNT signaling
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