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- 抗原 See all CXCR2 蛋白
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- 蛋白类型
- Synthetic Nanodisc
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human CXCR2 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 1-360) protein (GST tag)
CXCR2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 1-48) protein (Fc Tag)CXCR2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-X-C Motif) Receptor 2 (CXCR2) protein (Myc-DYKDDDDK Tag)CXCR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- 别名
- CXCR2 (CXCR2 产品)
- 别名
- CD182 Protein, CDw128b Protein, CMKAR2 Protein, IL8R2 Protein, IL8RA Protein, IL8RB Protein, CXC-R2 Protein, CXCR-2 Protein, CD128 Protein, CDw128 Protein, Cmkar2 Protein, Gpcr16 Protein, IL-8Rh Protein, IL-8rb Protein, Il8rb Protein, mIL-8RH Protein, C-X-C motif chemokine receptor 2 Protein, chemokine (C-X-C motif) receptor 2 Protein, Cxcr2 Protein, CXCR2 Protein
- 背景
- The protein is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
- 分子量
- The human full length CXCR2 protein has a MW of 40.8 kDa
- UniProt
- P25025
- 途径
- cAMP Metabolic Process
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