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TSH receptor 蛋白

TSHR 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
产品编号 ABIN7491755
发货至: 中国
  • 抗原 See all TSH receptor (TSHR) 蛋白
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    蛋白类型
    Synthetic Nanodisc
    宿主
    • 4
    • 1
    资源
    • 3
    • 1
    • 1
    HEK-293 Cells
    原理
    Human TSHR full length protein-synthetic nanodisc
    产品特性
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • 说明

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    别名
    TSHR (TSHR 产品)
    别名
    CHNG1 Protein, LGR3 Protein, hTSHR-I Protein, AI481368 Protein, hypothroid Protein, hyt Protein, pet Protein, TSHRA Protein, TSH-R Protein, thyroid stimulating hormone receptor Protein, tshr Protein, TSHR Protein, Tshr Protein
    背景
    The protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism.
    分子量
    The human full length TSHR protein has a MW of 86.8 kDa
    UniProt
    P16473
    途径
    Thyroid Hormone Synthesis
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