Malic Enzyme Complex, Mitochondrial (Mod2) 蛋白
-
- 抗原 See all Malic Enzyme Complex, Mitochondrial (Mod2) products
- Malic Enzyme Complex, Mitochondrial (Mod2)
- 蛋白类型
- Synthetic Nanodisc
-
宿主
- 人
-
资源
- HEK-293 Cells
- 原理
- Human MDR-1 full length protein-synthetic nanodisc
- 产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
-
Malic Enzyme Complex, Mitochondrial (Mod2) (AA 72-113) protein (Fc Tag)
Mod2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Malic Enzyme Complex, Mitochondrial (Mod2) (AA 1084-1419) protein (His-SUMO Tag)Mod2 宿主: Plasmodium falciparum 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Malic Enzyme Complex, Mitochondrial (Mod2) (AA 1084-1419) protein (His tag)Mod2 宿主: Plasmodium falciparum 宿主: 酵母菌 Recombinant > 90 % SDS
-
- 说明
-
Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
-
- 抗原
- Malic Enzyme Complex, Mitochondrial (Mod2)
- 别名
- MDR-1 (Mod2 产品)
- 别名
- Mdr Protein, Cd243 Protein, Mdr-1 Protein, Mod-2 Protein, Mod-2r Protein, Mod-2s Protein, Mod2-r Protein, Mod2-s Protein, ABC20 Protein, CD243 Protein, CLCS Protein, GP170 Protein, MDR1 Protein, P-GP Protein, PGY1 Protein, malic enzyme complex, mitochondrial Protein, ATP binding cassette subfamily B member 1 Protein, Mod2 Protein, ABCB1 Protein
- 背景
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
- 分子量
- The human full length MDR-1 protein has a MW of 141.5 kDa
- UniProt
- P08183
-
