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IL-10 Protein (AA 19-178) (His tag)

IL10 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7491255
发货至: 中国
  • 抗原 See all IL-10 (IL10) 蛋白
    IL-10 (IL10) (Interleukin 10 (IL10))
    蛋白类型
    Recombinant
    产品特性
    AA 19-178
    宿主
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    资源
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    HEK-293 Cells
    标记
    This IL-10 protein is labelled with His tag.
    原理
    Recombinant Human IL10 protein with N-terminal 6xHis tag
    特异性
    6xHis tag IL10 (Ser19-Asn178)
    产品特性
    Extracellular Domain Protein
    纯化方法
    Purified from cell culture supernatant by affinity chromatography
    纯度
    The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
    Top Product
    Discover our top product IL10 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    IL-10 (IL10) (Interleukin 10 (IL10))
    别名
    IL10 (IL10 产品)
    别名
    CSIF Protein, GVHDS Protein, IL-10 Protein, IL10A Protein, TGIF Protein, Il-10 Protein, IL10X Protein, interleukin 10 Protein, IL10 Protein, Il10 Protein
    背景
    The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
    分子量
    predicted molecular mass of 19.5 kDa after removal of the signal peptide. The apparent molecular mass of His-IL10 is 15-25 kDa due to glycosylation.
    UniProt
    P22301
    途径
    Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
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