MYDGF (D17Wsu104e)
(DNA segment, Chr 17, Wayne State University 104, expressed (D17Wsu104e))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌(E. Coli)
标记
This MYDGF protein is labelled with His tag.
原理
Recombinant Human Myeloid-derived Growth Factor is produced by our E.coli expression system and the target gene encoding Ser33-Leu173 is expressed with a 6His tag at the N-terminus.
产品特性
Extracellular Domain Protein
纯化方法
Affinity purification
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.
储存条件
-20 °C,-80 °C
储存方法
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
有效期
12 months
抗原
MYDGF (D17Wsu104e)
(DNA segment, Chr 17, Wayne State University 104, expressed (D17Wsu104e))
Myeloid-derived growth factor (MYDGF) is a secreted protein which belongs to the UPF0556 family. MYDGF was strongly expressed in spleen, prostate and lung, and weakly expressed in the left ventricle and liver. Bone marrow-derived monocyte and paracrine-acting protein promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). MYDGF stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. It inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. MYDGF is involved in endothelial cell proliferation and angiogenesis. It may serve as a prototypical example for the development of protein-based therapies for ischemic tissue repair.