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NGFB 蛋白

NGFB 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7455640
发货至: 中国
  • 抗原 See all NGFB 蛋白
    NGFB (Nerve Growth Factor beta (NGFB))
    蛋白类型
    Recombinant
    宿主
    • 7
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    • 1
    • 1
    • 1
    • 1
    • 1
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    资源
    • 8
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    HEK-293 Cells
    原理
    Recombinant Human Beta-Nerve Growth Factor is produced by our Mammalian expression system and the target gene encoding Ser122-Arg239 is expressed.
    产品特性
    Extracellular Domain Protein
    纯化方法
    Purified from cell culture supernatant by affinity chromatography
    纯度
    Greater than 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product NGFB 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.0.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    有效期
    12 months
  • 抗原
    NGFB (Nerve Growth Factor beta (NGFB))
    别名
    Beta-NGF (NGFB 产品)
    别名
    NGFB Protein, ngfb Protein, ns:zft386 Protein, xx:zft386 Protein, zgc:109730 Protein, hsan5 Protein, beta-ngf Protein, Ngfb Protein, Beta-NGF Protein, HSAN5 Protein, beta-NGF Protein, nerve growth factor Protein, nerve growth factor b (beta polypeptide) Protein, beta-Nerve growth factor Protein, nerve growth factor (beta polypeptide) Protein, NGF Protein, ngfb Protein, FPV072 Protein, FPV076 Protein, ngf Protein, Ngf Protein
    背景
    Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits a, β, and γ, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90 % sequence similarity with mouse protein and shows cross-species reactivity.
    分子量
    13.3 KDa
    UniProt
    P01138
    途径
    NF-kappaB Signaling, RTK signaling, Regulation of Cell Size
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