CXCL2 蛋白
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- 抗原 See all CXCL2 蛋白
- CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human C-X-C Motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Thr39-Asn107 is expressed.
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- Affinity purification
- 纯度
- Greater than 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CXCL2 蛋白
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Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) protein
CXCL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) proteinCXCL2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) proteinCXCL2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 1-107) protein (GST tag)CXCL2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 32-100) protein (His tag)CXCL2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 35-107) protein (His tag)CXCL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 28-100) protein (His tag)CXCL2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 1-100) protein (GST tag)CXCL2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 35-107) protein (His-DYKDDDDK-Strep II Tag)CXCL2 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 28-100) protein (His tag)CXCL2 宿主: 小鼠 宿主: Yeast (Pichia pastoris) Recombinant > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))
- 别名
- CXCL2 (CXCL2 产品)
- 别名
- CINC-2a Protein, GRO2 Protein, GROb Protein, MGSA-b Protein, MIP-2a Protein, MIP2 Protein, MIP2A Protein, SCYB2 Protein, GRO3 Protein, Gro2 Protein, MIP-2 Protein, Mgsa-b Protein, Mip2 Protein, Scyb Protein, Scyb2 Protein, Mip-2 Protein, GROB Protein, MIP-2alpha Protein, C-X-C motif chemokine ligand 2 Protein, chemokine (C-X-C motif) ligand 2 Protein, CXCL2 Protein, Cxcl2 Protein
- 背景
- Chemokine Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. It can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
- 分子量
- 7.67 KDa
- UniProt
- P19875
- 途径
- Cellular Response to Molecule of Bacterial Origin
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