Tissue factor Protein (AA 33-251) (Fc Tag)
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- 抗原 See all Tissue factor (F3) 蛋白
- Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 33-251
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Tissue factor protein is labelled with Fc Tag.
- 原理
- Recombinant human CD142 protein with C-terminal human Fc tag
- 特异性
- CD142 (Ser33-Glu251) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- Purified from cell culture supernatant by affinity chromatography
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product F3 蛋白
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Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 33-251) protein (His tag)
F3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 35-248) protein (His tag)F3 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 31-251) protein (His tag)F3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 45-154) protein (GST tag)F3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) protein (His tag)F3 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) protein (His tag)F3 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (Active) protein (His tag)F3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 33-251) protein (Fc Tag)F3 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 33-251) (Active) protein (His tag)F3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))
- 别名
- CD142 (F3 产品)
- 别名
- CD142 Protein, TF Protein, TFA Protein, PRO1557 Protein, PRO2086 Protein, TFQTL1 Protein, f3 Protein, AA409063 Protein, Cf-3 Protein, Cf3 Protein, tf Protein, zgc:112151 Protein, coagulation factor III, tissue factor Protein, transferrin Protein, coagulation factor IIIa Protein, coagulation factor III Protein, tissue factor Protein, coagulation factor IIIb Protein, coagulation factor III (thromboplastin, tissue factor) S homeolog Protein, F3 Protein, TF Protein, f3a Protein, tf Protein, f3b Protein, f3.S Protein
- 背景
- This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
- 分子量
- predicted molecular mass of 50.9 kDa after removal of the signal peptide. The apparent molecular mass of CD142-hFc is 55-70kDa due to glycosylation.
- UniProt
- P13726
- 途径
- Positive Regulation of Endopeptidase Activity, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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