SLIT2 Protein (His tag)
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- 抗原 See all SLIT2 蛋白
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SLIT2 protein is labelled with His tag.
- 原理
- Human SLIT2 Protein, His Tag
- 序列
- Leu 271 - Ser 479
- 产品特性
- Human SLIT2, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 271 - Ser 479 (Accession # O94813-1).
- 纯度
- 95,00 %
- 内毒素水平
- 1.0 EU per μg
- Top Product
- Discover our top product SLIT2 蛋白
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Slit Homolog 2 (Drosophila) (SLIT2) (AA 1361-1460) protein (GST tag)
SLIT2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Slit Homolog 2 (Drosophila) (SLIT2) (Active) proteinSLIT2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
Slit Homolog 2 (Drosophila) (SLIT2) protein (Myc-DYKDDDDK Tag)SLIT2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 说明
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This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.3 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 100 mM HEPES,500 mM NaCl, pH 7.0
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
- 别名
- SLIT2 (SLIT2 产品)
- 别名
- SLIL3 Protein, Slit-2 Protein, Drad-1 Protein, E030015M03Rik Protein, E130320P19Rik Protein, Slil3 Protein, mKIAA4141 Protein, Slit Protein, slil3 Protein, slit-2 Protein, slit2-a Protein, SLIT2 Protein, slit guidance ligand 2 Protein, slit homolog 2 (Drosophila) Protein, slit guidance ligand 2 S homeolog Protein, SLIT2 Protein, Slit2 Protein, slit2 Protein, slit2.S Protein
- 背景
- Synonyms:SLIT2,Slit homolog 2 protein,SLIL3,Slit-2,Description:Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
- 分子量
- 25.3 kDa
- NCBI登录号
- NP_004778
- 途径
- Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration
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