HLAG
(HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))
蛋白类型
Recombinant
产品特性
Monomer
宿主
Cynomolgus
资源
HEK-293 Cells
标记
This HLAG protein is labelled with HLA-G.
原理
Cynomolgus HLA-G & B2M & Peptide (RIIPRHLQL) Monomer Protein
序列
Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide
特异性
Uni-Prot: E0WKX9 (HLA-G), Q8SPW0 (B2M), RIIPRHLQL
产品特性
Recombinant Cynomolgus HLA-G & B2M & Peptide (RIIPRHLQL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
纯度
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
缓冲液
Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
储存条件
-20 °C,-80 °C
储存方法
-20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
有效期
12 months
抗原
HLAG
(HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))
MHC-G Protein, B-F Protein, B-F-S04 Protein, B-F-S05 Protein, B-F-S06 Protein, B-F-S07 Protein, B-FI Protein, B-FIV Protein, BF2 Protein, BFa2 Protein, BFw-03 Protein, BFw-05 Protein, BFz-01 Protein, major histocompatibility complex, class I, G Protein, MHC BF1 class I Protein, HLA-G Protein, BF1 Protein
背景
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
分子量
50.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.