CAMK1 蛋白
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- 抗原 See all CAMK1 蛋白
- CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human CAMK1/CaMKI-alpha Protein
- 序列
- Leu 2-Leu 370
- 产品特性
- A DNA sequence encoding the human CAMK1 (NP_003647.1) (Leu 2-Leu 370) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- Please contact us for more information.
- Top Product
- Discover our top product CAMK1 蛋白
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Calcium/calmodulin-Dependent Protein Kinase I (CAMK1) (AA 1-370) protein (GST tag)
CAMK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Calcium/calmodulin-Dependent Protein Kinase I (CAMK1) (AA 271-370) protein (GST tag)CAMK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Calcium/calmodulin-Dependent Protein Kinase I (CAMK1) protein (Myc-DYKDDDDK Tag)CAMK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 说明
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42 kDa
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tirs, 150 mM NaCl, 10 % glycerol, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))
- 别名
- CAMK1 (CAMK1 产品)
- 别名
- CAMKI Protein, Camki Protein, Gaip Protein, CG1495 Protein, Calcium/calmodulin-dependent protein kinase Protein, CamKI Protein, Dmel\\CG1495 Protein, caMKI Protein, camKI Protein, dCKI Protein, AI505105 Protein, CaMKIalpha Protein, D6Ertd263e Protein, cam-kia Protein, camk1 Protein, camkI Protein, calcium/calmodulin dependent protein kinase I Protein, calcium/calmodulin-dependent protein kinase I Protein, Calcium/calmodulin-dependent protein kinase I Protein, calcium/calmodulin-dependent protein kinase I L homeolog Protein, CAMK1 Protein, Camk1 Protein, CaMKI Protein, camk1.L Protein
- 背景
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Background: Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of the protein kinase superfamily and CaMK subfamily. It contains one protein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.
Synonym: Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaM-KI; CaM Kinase I Alpha; CaMKI-Alpha; CAMK1
- 分子量
- 41.5 kDa
- NCBI登录号
- NP_003647
- 途径
- Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Smooth Muscle Cell Migration
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