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BTN2A2 Protein (Biotin)

BTN2A2 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319888
发货至: 中国
  • 抗原 See all BTN2A2 蛋白
    BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))
    蛋白类型
    Recombinant
    宿主
    • 3
    • 1
    资源
    • 2
    • 1
    • 1
    人细胞
    标记
    This BTN2A2 protein is labelled with Biotin.
    原理
    Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated
    序列
    Gln33-Val237
    产品特性
    Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.
    纯度
    >95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product BTN2A2 蛋白
  • 说明

    55-80 kDa

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))
    别名
    BTN2A2 (BTN2A2 产品)
    别名
    BT2.2 Protein, BTF2 Protein, Btn2 Protein, D030063K05 Protein, btf2 Protein, bt2.2 Protein, MGC88971 Protein, BTN2A2 Protein, BTN2A1 Protein, butyrophilin subfamily 2 member A2 Protein, butyrophilin, subfamily 2, member A2 Protein, butyrophilin subfamily 2 member A2 L homeolog Protein, BTN2A2 Protein, Btn2a2 Protein, btn2a2 Protein, btn2a2.L Protein, LOC100065830 Protein, LOC100348076 Protein
    背景

    Background: Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naive B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

    Synonym: Butyrophilin subfamily 2 member A2, BTN2A2

    分子量
    51.5 kDa
    UniProt
    Q8WVV5
    途径
    Activated T Cell Proliferation
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