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ANGPTL3 Protein (Fc Tag)

ANGPTL3 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319869
发货至: 中国
  • 抗原 See all ANGPTL3 蛋白
    ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
    蛋白类型
    Recombinant
    宿主
    • 12
    • 6
    • 2
    • 1
    资源
    • 9
    • 6
    • 2
    • 2
    • 1
    人细胞
    标记
    This ANGPTL3 protein is labelled with Fc Tag.
    原理
    Recombinant Human Angiopoietin-related Protein 3/ANGPTL3 (C-Fc)
    序列
    Ser17-Pro220
    产品特性
    Recombinant Human Angiopoietin-related Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser17-Pro220 is expressed with a Fc tag at the C-terminus.
    纯度
    >95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product ANGPTL3 蛋白
  • 说明

    60-70 kDa

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
    别名
    Angiopoietin-related protein 3 (ANGPTL3 产品)
    别名
    fb60e11 Protein, fb66h02 Protein, wu:fb60e11 Protein, wu:fb66h02 Protein, zgc:111943 Protein, ANGPTL3 Protein, LOC100230785 Protein, ANG-5 Protein, ANGPT5 Protein, ANL3 Protein, FHBL2 Protein, hypl Protein, angiopoietin-like 3 Protein, angiopoietin like 3 Protein, angptl3 Protein, ANGPTL3 Protein, Angptl3 Protein
    背景

    Background: Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRβ or PPARβ.

    Synonym: Angiopoietin-related protein 3, ANGPTL3, Angiopoietin-5, ANG-5, Angiopoietin-like protein 3, ANGPT5

    分子量
    50.7 kDa
    UniProt
    Q9Y5C1
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