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CD19 Protein (Fc Tag)

CD19 宿主: 猕猴 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7321005
发货至: 中国
  • 抗原 See all CD19 蛋白
    CD19 (CD19 Molecule (CD19))
    蛋白类型
    Recombinant
    宿主
    • 27
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    猕猴
    资源
    • 26
    • 4
    • 3
    • 2
    • 1
    • 1
    人细胞
    标记
    This CD19 protein is labelled with Fc Tag.
    原理
    Recombinant Rhesus macaque CD19 Protein (Fc Tag)
    序列
    Pro20-Lys292
    产品特性
    Recombinant Rhesus macaque CD19 is produced by our Mammalian expression system and the target gene encoding Pro20-Lys292 is expressed with a Fc tag at the C-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product CD19 蛋白
  • 说明

    80-110 kDa

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD19 (CD19 Molecule (CD19))
    别名
    CD19 (CD19 产品)
    别名
    B4 Protein, CVID3 Protein, AW495831 Protein, CD19 Protein, CD19 molecule Protein, CD19 antigen Protein, CD19 Protein, Cd19 Protein
    背景

    Background: CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.

    Synonym: B-Lymphocyte Antigen CD19, B-Lymphocyte Surface Antigen B4, Differentiation Antigen CD19, T-Cell Surface Antigen Leu-12, CD19

    分子量
    57.2 kDa
    UniProt
    F7F486
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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