UPB1 Protein (His tag)
-
- 抗原 See all UPB1 蛋白
- UPB1 (Ureidopropionase, beta (UPB1))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- 大肠杆菌(E. Coli)
- 标记
- This UPB1 protein is labelled with His tag.
- 原理
- Recombinant Human BUP1 Protein (His Tag)
- 序列
- Met 1-Glu384
- 产品特性
- Recombinant Human beta-Ureidopropionase is produced by our E.coli expression system and the target gene encoding Met1-Glu384 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product UPB1 蛋白
-
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- UPB1 (Ureidopropionase, beta (UPB1))
- 别名
- BUP1 (UPB1 产品)
- 别名
- MGC82230 Protein, wu:fb69e03 Protein, zgc:64020 Protein, BUP1 Protein, AI195023 Protein, Bup1 Protein, ureidopropionase, beta S homeolog Protein, beta-ureidopropionase 1 Protein, ureidopropionase, beta Protein, UreidoPropionase Beta Protein, upb1.S Protein, UPB1 Protein, upb1 Protein, upb-1 Protein, Upb1 Protein
- 背景
-
Background: β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta aminoisobutyric acid, respectively. Defects in β-Ureidopropionase are the cause of β-Ureidopropionase deficiency that is characterized by muscular hypotonia, dystonic movements, scoliosis, microcephaly and severe developmental delay.
Synonym: Beta-Ureidopropionase, BUP-1, Beta-Alanine Synthase, N-Carbamoyl-Beta-Alanine Amidohydrolase, UPB1, BUP1
- 分子量
- 44.2 kDa
- UniProt
- Q9UBR1
-