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USP7 蛋白

USP7 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 98 % as determined by reducing SDS-PAGE.
产品编号 ABIN7198568
发货至: 中国
  • 抗原 See all USP7 蛋白
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    蛋白类型
    Recombinant
    宿主
    资源
    • 2
    • 1
    • 1
    • 1
    • 1
    Baculovirus infected Insect Cells
    原理
    Recombinant Human USP7/HAUSP Protein (aa 208-560)
    序列
    Lys 208-Glu 560
    产品特性
    A DNA sequence encoding the amino acid sequence (Lys 208-Glu 560) of human USP7 (NP_003461.2) expressed and purified, with two additional aa (Gly & Pro) at the N-terminus.
    纯度
    > 98 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product USP7 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, pH 8.0
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    别名
    USP7/HAUSP (USP7 产品)
    别名
    CG1490 Protein, Dmel\\CG1490 Protein, USP7 Protein, 2210010O09Rik Protein, AA409944 Protein, AA617399 Protein, AU019296 Protein, AW548146 Protein, C80752 Protein, Hausp Protein, HAUSP Protein, TEF1 Protein, UBP Protein, Ubiquitin-specific protease 7 Protein, ubiquitin carboxyl-terminal hydrolase 7 Protein, ubiquitin specific peptidase 7 Protein, Usp7 Protein, LOC100201254 Protein, USP7 Protein
    背景

    Background: Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein which belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 stimulates lytic infection and the reactivation of quiescent viral genomes. ICP0 interacts very strongly with USP7. USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed.

    Synonym: HAUSP;TEF1

    分子量
    41 kDa
    NCBI登录号
    NP_003461
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