TNFRSF10A Protein (His tag)
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- 抗原 See all TNFRSF10A 蛋白
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TNFRSF10A protein is labelled with His tag.
- 原理
- Recombinant Human TRAILR1/TNFRSF10A Protein (His Tag)(Active)
- 序列
- Met 1-Asn 239
- 产品特性
- A DNA sequence encoding the human TNFRSF10A (NP_003835.2) extracellular domain (Met 1-Asn 239) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL.The ED50 for this effect is typically 50-200 ng/ml in the presence of 20 ng/ml Recombinant Human TRAIL/TNFSF10.
- Top Product
- Discover our top product TNFRSF10A 蛋白
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Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag,Biotin)
TNFRSF10A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 34-239) protein (Fc Tag)TNFRSF10A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag)TNFRSF10A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 103-239) protein (His-DYKDDDDK-Strep II Tag)TNFRSF10A 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (Fc Tag)TNFRSF10A 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His tag)TNFRSF10A 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 379-445) protein (His-IF2DI Tag)TNFRSF10A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 105-204) protein (GST tag)TNFRSF10A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (His tag)TNFRSF10A 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- 别名
- TRAILR1/TNFRSF10A (TNFRSF10A 产品)
- 别名
- APO2 Protein, CD261 Protein, DR4 Protein, TRAILR-1 Protein, TRAILR1 Protein, TNFRSF10A Protein, TNF receptor superfamily member 10a Protein, tumor necrosis factor receptor superfamily member 26 Protein, tumor necrosis factor receptor superfamily, member 10a Protein, TNFRSF10A Protein, LOC510798 Protein
- 背景
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Background: Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: APO2;CD261;DR4;MGC9365;TNFRSF10A;TRAILR-1;TRAILR1
- 分子量
- 15.7 kDa
- NCBI登录号
- NP_003835
- 途径
- Apoptosis, Positive Regulation of Endopeptidase Activity
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