TGFBR1 Protein (His tag,Fc Tag)
-
- 抗原 See all TGFBR1 蛋白
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This TGFBR1 protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Human TGFBR1/ALK-5 Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Glu 125
- 产品特性
- A DNA sequence encoding the human TGFBR1 (NP_004603.1) extracellular domain (Met 1-Glu 125) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA. Immobilized mouse CD105 at 10 μg/ml (100 μl/well) can bind human TGFRB1 with a linear ranger of 6.4-800 ng/ml.2. Measured by its ability to bind human CD105 in a functional ELISA.
- Top Product
- Discover our top product TGFBR1 蛋白
-
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (mFc-Avi Tag)
TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) protein (GST tag)TGFBR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-125) protein (mFc-Avi Tag,Biotin)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 200-503) (Active) protein (GST tag,His tag)TGFBR1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- TGFBR1/ALK-5 (TGFBR1 产品)
- 别名
- AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein
- 背景
-
Background: Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells. Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Dietz syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5).
Synonym: AAT5,ACVRLK4,ALK-5,ALK5,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,tbetaR-I,TGFR-1
- 分子量
- 38.8 kDa
- NCBI登录号
- NP_004603
- 途径
- Growth Factor Binding
-
