TLK2 蛋白
Quick Overview for TLK2 蛋白 (ABIN7317071)
抗原
See all TLK2 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human TLK2/PKU-ALPHA Protein
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序列
- Leu 397-Asn772
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产品特性
- A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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!探索我们的预定义定制蛋白和定制蛋白服务!Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 115,504.49 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 172,528.32 ¥您的项目需要进一步定制吗?联系我们,了解我们的定制蛋白解决方案
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- TLK2 (Tousled-Like Kinase 2 (TLK2))
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别名
- TLK2/PKU-ALPHA
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背景
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Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
Synonym: HsHPK;PKU-ALPHA
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分子量
- 43.6 kDa
抗原
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