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Thrombopoietin Protein (THPO) (His tag)

THPO 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7320657
发货至: 中国
  • 抗原 See all Thrombopoietin (THPO) 蛋白
    Thrombopoietin (THPO)
    蛋白类型
    Recombinant
    宿主
    • 11
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    小鼠
    资源
    • 23
    • 3
    • 2
    • 2
    • 1
    • 1
    人细胞
    标记
    This Thrombopoietin protein is labelled with His tag.
    原理
    Recombinant Mouse Thrombopoietin/TPO Protein (His Tag)
    序列
    Ser22-Thr356
    产品特性
    Recombinant Mouse Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22-Thr356 is expressed with a 6His tag at the N-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product THPO 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Thrombopoietin (THPO)
    别名
    Thrombopoietin/TPO (THPO 产品)
    背景

    Background: Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71 % and 81 % aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

    Synonym: Thrombopoietin,C-mpl ligand,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,Myeloproliferative leukemia virus oncogene ligand,THPO

    分子量
    36.4 kDa
    UniProt
    P40226
    途径
    JAK/STAT Signaling, Hormone Activity
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