Thrombomodulin Protein (THBD) (AA 17-517) (His tag)
This Recombinant Thrombomodulin protein is expressed in HEK-293 Cells.
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产品编号 ABIN7320771
发货至:
中国
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Quick Overview for Thrombomodulin Protein (THBD) (AA 17-517) (His tag) (ABIN7320771)
抗原
See all Thrombomodulin (THBD) 蛋白
Thrombomodulin (THBD)
蛋白类型
Recombinant
宿主
小鼠
资源
HEK-293 Cells
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 17-517
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标记
- This Thrombomodulin protein is labelled with His tag.
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原理
- Recombinant Mouse Thrombomodulin/THBD Protein (His Tag)
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序列
- Leu17-Ser517
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产品特性
- Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Thrombomodulin (THBD) (AA 1-517) protein (His tag)
THBD 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- Thrombomodulin (THBD)
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别名
- Thrombomodulin/THBD
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背景
- BDCA-3,CD141,Fetomodulin,TM,Thbd,Thrombomodulin,Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.
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分子量
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Calculated MW: 54.6 kDa
Observed MW: 85-90 kDa
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基因ID
- 21824
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UniProt
- P15306
抗原
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