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TXNDC17 蛋白

TXNDC17 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 97 % as determined by reducing SDS-PAGE.
产品编号 ABIN7198224
发货至: 中国
  • 抗原 See all TXNDC17 蛋白
    TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))
    蛋白类型
    Recombinant
    宿主
    • 3
    • 1
    • 1
    资源
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    原理
    Recombinant Human TXNDC17/TRP14/TXNL5 Protein
    序列
    Met 1-Asp 123
    产品特性
    A DNA sequence encoding the mature form of human TXNDC17 (Q9BRA2) (Met 1-Asp 123) was expressed and purified, with an initial Met.
    纯度
    > 97 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product TXNDC17 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))
    别名
    TXNDC17//TXNL5 (TXNDC17 产品)
    别名
    TRP14 Protein, TXNL5 Protein, 4831443O22Rik Protein, D11Ertd672e Protein, Txnl5 Protein, txnl5 Protein, zgc:91920 Protein, thioredoxin domain containing 17 Protein, TXNDC17 Protein, Txndc17 Protein, txndc17 Protein
    背景

    Background: Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I  membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: TRP14;TXNL5

    分子量
    13.9 kDa
    UniProt
    Q9BRA2
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