SLAMF6 Protein (AA 28-225) (His tag)
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- 抗原 See all SLAMF6 蛋白
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 28-225
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宿主
- 人
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资源
- 人细胞
- 标记
- This SLAMF6 protein is labelled with His tag.
- 原理
- Recombinant Human SLAMF6/Ly108 Protein (aa 28-225, His Tag)(Active)
- 序列
- Leu28-Lys225
- 产品特性
- Recombinant Human SLAM Family Member 6 is produced by our Mammalian expression system and the target gene encoding Leu28-Lys225 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to induce IFN-γ secretion by PBMC cells.
- Top Product
- Discover our top product SLAMF6 蛋白
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SLAM Family Member 6 (SLAMF6) (AA 22-226) protein (Fc Tag)
SLAMF6 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) (AA 22-226) protein (His-Avi Tag)SLAMF6 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) (AA 20-225) protein (His tag)SLAMF6 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) (AA 1-271) protein (GST tag)SLAMF6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
SLAM Family Member 6 (SLAMF6) (Active) protein (His tag)SLAMF6 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
SLAM Family Member 6 (SLAMF6) (AA 22-226) protein (mFc-His Tag)SLAMF6 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- 别名
- SLAMF6/Ly108 (SLAMF6 产品)
- 别名
- SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein
- 背景
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Background: SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.
Synonym: SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI, Ly108, NTBA, SF2000
- 分子量
- 23.4 kDa
- UniProt
- Q96DU3
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