S100A11 蛋白
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- 抗原 See all S100A11 蛋白
- S100A11 (S100 Calcium Binding Protein A11 (S100A11))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human S100A11 Protein
- 序列
- Met1-Thr105
- 产品特性
- Recombinant Human S100A11 is produced by our E.coli expression system and the target gene encoding Met1-Thr105 is expressed.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- Discover our top product S100A11 蛋白
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S100 Calcium Binding Protein A11 (S100A11) (Active) protein (His tag)
S100A11 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE. Active
S100 Calcium Binding Protein A11 (S100A11) (AA 1-105) protein (His-IF2DI Tag)S100A11 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
S100 Calcium Binding Protein A11 (S100A11) (AA 1-105) protein (GST tag)S100A11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S100 Calcium Binding Protein A11 (S100A11) (AA 10-87) protein (GST tag)S100A11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS,1 mM DTT, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- S100A11 (S100 Calcium Binding Protein A11 (S100A11))
- 别名
- S100A11 (S100A11 产品)
- 别名
- MLN70 Protein, S100C Protein, PCALG Protein, EMAPI Protein, Emap1 Protein, S100a14 Protein, S100c Protein, cal Protein, S100 calcium binding protein A11 Protein, S100A11 Protein, S100a11 Protein
- 背景
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Background: S100A11 is a member of the S100 family of calcium binding proteins. Human S100A11 contains two EF hand motifs and shares 82 % amino acid sequence identity with mouse and rat S100A11. It forms covalent homodimers upon transglutamination and also disulfide-linked tetramers. S100A11 is secreted by keratinocytes and can be crosslinked into the cornified envelope of the skin. Dimerization enhances its ability to signal through RAGE on keratinocytes, induce the production of EGF family proteins, and induce cell proliferation. Dimerization also enables S100A11 to bind RAGE on chondrocytes, leading to chondrocyte hypertrophy and catabolism of the cartilage matrix. S100A11 is additionally found in the cytosol where it becomes phosphorylated and translocates to the nucleus in response to DNA damage, RELM alpha exposure, or elevated extracellular calcium concentrations. Calcium also promotes S100A11 association with S100B as well as Annexins A1, A2, and A6. S100A11-Annexin A2 complexes are recruited to sites of plasma membrane damage where they facilitate membrane repair in migrating cancer cells. S100A11 is upregulated in various cancers and supports tumor cell proliferation, invasion, and migration. In addition, S100A11 is produced in the ovary, and it acts on cumulus cells to inhibit oocyte fertilization.
Synonym: Protein S100-A11, Calgizzarin, Metastatic lymph node gene 70 protein, MLN 70, Protein S100-C, S100 calcium-binding protein A11, S100A11, MLN70, S100C
- 分子量
- 11.7 kDa
- UniProt
- P31949
- 途径
- S100 Proteins
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