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RNASET2 Protein (His tag)

RNASET2 宿主: 人 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319474
发货至: 中国
  • 抗原 See all RNASET2 蛋白
    RNASET2 (Ribonuclease T2 (RNASET2))
    蛋白类型
    Recombinant
    宿主
    • 6
    • 2
    • 2
    • 1
    资源
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    人细胞
    标记
    This RNASET2 protein is labelled with His tag.
    原理
    Recombinant Human RNASET2 Protein (Human Cells, His Tag)
    序列
    Asp25-His256
    产品特性
    Recombinant Human Ribonuclease T2 is produced by our Mammalian expression system and the target gene encoding Asp25-His256 is expressed with a 6His tag at the C-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product RNASET2 蛋白
  • 限制
    仅限研究用
  • 状态
    Frozen, Liquid
    缓冲液
    Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,20 % Glycerol, pH 7.5.
    储存条件
    -20 °C
    储存方法
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原
    RNASET2 (Ribonuclease T2 (RNASET2))
    别名
    RNASET2 (RNASET2 产品)
    别名
    RNASE6PL Protein, bA514O12.3 Protein, MGC83874 Protein, MGC145364 Protein, dre2 Protein, wu:fc10c06 Protein, zgc:113369 Protein, ribonuclease T2 Protein, ribonuclease T2 L homeolog Protein, ribonuclease t2 Protein, RNASET2 Protein, Rnaset2 Protein, rnaset2.L Protein, rnaset2 Protein, TM1040_2631 Protein, RPE_1409 Protein, Bind_1696 Protein, Dd586_2225 Protein, Nhal_0810 Protein, Snov_2442 Protein, Fbal_2689 Protein, Nitsa_0808 Protein, Mesop_3495 Protein
    背景

    Background: RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

    Synonym: Ribonuclease T2,3.1.27.-,Ribonuclease 6,RNASE6PL

    分子量
    28.2 kDa
    UniProt
    O00584
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