PRDM2 蛋白
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- 抗原 See all PRDM2 蛋白
- PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human PRDM2/RIZ1 Protein
- 序列
- Met 1-Ala 200
- 产品特性
- A DNA sequence encoding the N-terminal segment of human PRDM2 (NP_036363.2) (Met 1-Ala 200), containing the SET domian, was expressed, with two additonal amino acids (Gly & Pro) at the N-terminus.
- 纯度
- > 96 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PRDM2 蛋白
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PR Domain Containing 2, with ZNF Domain (PRDM2) (AA 2-200) protein (His tag)
PRDM2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
PR Domain Containing 2, with ZNF Domain (PRDM2) (AA 1606-1705) protein (GST tag)PRDM2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
PR Domain Containing 2, with ZNF Domain (PRDM2) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)PRDM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 0.5 mM DTT, 0.5 mM GSH, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))
- 别名
- PRDM2/RIZ1 (PRDM2 产品)
- 别名
- MGC114763 Protein, prdm2 Protein, riz Protein, kmt8 Protein, riz1 Protein, riz2 Protein, mtb-zf Protein, humhoxy1 Protein, PRDM2 Protein, HUMHOXY1 Protein, KMT8 Protein, MTB-ZF Protein, RIZ Protein, RIZ1 Protein, RIZ2 Protein, 4833427P12Rik Protein, E330024L24Rik Protein, Gm1033 Protein, Gm19732 Protein, Riz Protein, Riz1 Protein, Znfpr1c1 Protein, PR domain containing 2, with ZNF domain S homeolog Protein, PR domain containing 2, with ZNF domain b Protein, PR domain containing 2, with ZNF domain Protein, PR domain zinc finger protein 2 Protein, PR/SET domain 2 Protein, prdm2.S Protein, prdm2b Protein, prdm2 Protein, LOC100350859 Protein, PRDM2 Protein, Prdm2 Protein
- 背景
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Background: PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3.
Synonym: HUMHOXY1,KMT8,MTB-ZF,RIZ,RIZ1,RIZ2
- 分子量
- 23 kDa
- NCBI登录号
- NP_036363
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