Oncostatin M Receptor Protein (OSMR) (AA 1-740) (His tag)
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- 抗原 See all Oncostatin M Receptor (OSMR) 蛋白
- Oncostatin M Receptor (OSMR)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-740
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Oncostatin M Receptor protein is labelled with His tag.
- 原理
- Recombinant Human OSMR/IL31RB Protein (aa 1-740, His Tag)
- 序列
- Met 1-Met 740
- 产品特性
- A DNA sequence encoding the human OSMR (NP_003990.1) extracellular domain (Met 1-Met 740) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 96 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OSMR 蛋白
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Oncostatin M Receptor (OSMR) (AA 28-740) protein (His tag)
OSMR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Oncostatin M Receptor (OSMR) (AA 28-737) protein (His tag)OSMR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Oncostatin M Receptor (OSMR) (AA 24-737) protein (His tag)OSMR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Oncostatin M Receptor (OSMR) (AA 1-342) protein (GST tag)OSMR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Oncostatin M Receptor (OSMR) (AA 141-240) protein (GST tag)OSMR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Oncostatin M Receptor (OSMR)
- 别名
- OSMR/IL31RB (OSMR 产品)
- 别名
- OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
- 背景
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Background: Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
Synonym: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR,OSMRB,PLCA1
- 分子量
- 82.6 kDa
- NCBI登录号
- NP_003990
- 途径
- JAK/STAT Signaling, Growth Factor Binding
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