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Nicastrin Protein (NCSTN) (His tag)

NCSTN 宿主: 人 宿主: HEK-293 Cells Recombinant > 93 % as determined by reducing SDS-PAGE.
产品编号 ABIN7197196
发货至: 中国
  • 抗原 See all Nicastrin (NCSTN) 蛋白
    Nicastrin (NCSTN)
    蛋白类型
    Recombinant
    宿主
    • 3
    • 2
    • 2
    资源
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This Nicastrin protein is labelled with His tag.
    原理
    Recombinant Human Nicastrin/NCSTN Protein (His Tag)
    序列
    Met 1-Glu 669
    产品特性
    A DNA sequence encoding the human NCSTN (NP_056146.1) extracellular domain (Met 1-Glu 669) was expressed, with a polyhistidine tag at the C-terminus.
    纯度
    > 93 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product NCSTN 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Nicastrin (NCSTN)
    别名
    Nicastrin/NCSTN (NCSTN 产品)
    背景

    Background: Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing evidences have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). In addition, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro.

    Synonym: APH2,ATAG1874,KIAA0253,NCSTN,RP11-517F10.1

    分子量
    72.4 kDa
    NCBI登录号
    NP_056146
    途径
    Notch Signaling, Neurotrophin Signaling Pathway
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