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Nectin-2 Protein (NECTIN2) (Fc Tag)

NECTIN2 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319926
发货至: 中国
  • 抗原 See all Nectin-2 (NECTIN2) products
    Nectin-2 (NECTIN2)
    蛋白类型
    Recombinant
    宿主
    • 1
    • 1
    资源
    • 2
    人细胞
    标记
    This Nectin-2 protein is labelled with Fc Tag.
    原理
    Recombinant Human PVRL2/Nectin-2/CD112 (C-mIgG2a Fc)
    序列
    Gln32-Leu360
    产品特性
    Recombinant Human Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Leu360 is expressed with a mIgG2a Fc tag at the C-terminus.
    纯度
    >95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Nectin-2 (NECTIN2)
    别名
    PVRL2/Nectin-2/CD112 (NECTIN2 产品)
    别名
    CD112 Protein, HVEB Protein, PRR2 Protein, PVRR2 Protein, AI325026 Protein, AI987993 Protein, Cd112 Protein, MPH Protein, Pvr Protein, Pvs Protein, nectin-2 Protein, nectin cell adhesion molecule 2 Protein, NECTIN2 Protein, Nectin2 Protein
    背景

    Background: CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

    Synonym: Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, HveB, Nectin-2, CD112, PVRL2, HVEB, PRR2

    分子量
    62.6 kDa
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