MAPK12 蛋白
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- 抗原 See all MAPK12 蛋白
- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Human ERK3/MAPK12 Protein
- 序列
- Met 1-Leu 367
- 产品特性
- A DNA sequence encoding the human MAPK12 (P53778) (Met1-Leu367) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product MAPK12 蛋白
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Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)
MAPK12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 251-367) protein (GST tag)MAPK12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (GST tag)MAPK12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA, KAA
Mitogen-Activated Protein Kinase 12 (MAPK12) protein (GST tag,His tag)MAPK12 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
- 别名
- ERK3/MAPK12 (MAPK12 产品)
- 别名
- ATMPK12 Protein, MAPK12 Protein, T3F17.28 Protein, mitogen-activated protein kinase 12 Protein, MGC160082 Protein, si:dkey-14d8.5 Protein, erk6 Protein, etID309866.18 Protein, mapk12 Protein, sapk3 Protein, wu:fa05c12 Protein, zgc:101695 Protein, ERK3 Protein, ERK6 Protein, P38GAMMA Protein, PRKM12 Protein, SAPK-3 Protein, SAPK3 Protein, AW123708 Protein, Erk6 Protein, P38gamma Protein, Prkm12 Protein, Sapk3 Protein, mitogen-activated protein kinase 12 Protein, mitogen-activated protein kinase 12b Protein, mitogen-activated protein kinase 12a Protein, MPK12 Protein, MAPK12 Protein, mapk12b Protein, mapk12a Protein, Mapk12 Protein
- 背景
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Background: ERK3; also known as MAPK12 and p38-gamma; belongs to the protein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Synonym: ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma
- 分子量
- 42.1 kDa
- UniProt
- P53778
- 途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins
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