MMP3 蛋白
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- 抗原 See all MMP3 蛋白
- MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human MMP-3 Protein (Active)
- 序列
- Tyr 18-Thr 272
- 产品特性
- A DNA sequence encoding the human MMP3 (AAA36321.1) N-terminal fragment (Tyr 18-Thr 272) was expressed and purified.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nva-WR-K(Dnp)-NH2, AnaSpec, Catalog # 27114.The specific activity is >300 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Chymotrypsin for an activated form)
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- Discover our top product MMP3 蛋白
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Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 100-273) protein (His tag)
MMP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 22-131) protein (GST tag)MMP3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 1-477) protein (GST tag)MMP3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 10 mM CaCL2, 1uM ZnCL2, 50 mM NaCl, 0.5 % Brij35, pH 7.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
- 别名
- MMP-3 (MMP3 产品)
- 别名
- CHDS6 Protein, MMP-3 Protein, SL-1 Protein, STMY Protein, STMY1 Protein, STR1 Protein, SLN-1 Protein, SLN1 Protein, STR-1 Protein, Stmy1 Protein, Str1 Protein, MMP10 Protein, chds6 Protein, mmp-3 Protein, mmp13 Protein, mmp3 Protein, sl-1 Protein, stmy Protein, stmy1 Protein, str1 Protein, matrix metallopeptidase 3 Protein, matrix metallopeptidase 3 (stromelysin 1, progelatinase) Protein, matrix metallopeptidase 3 L homeolog Protein, MMP3 Protein, Mmp3 Protein, mmp3.L Protein
- 背景
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Background: Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
Synonym: Stromelysin-1, SL-1, Matrix metalloproteinase-3,Transin-1, MMP3, STMY1,CHDS6,MMP-3,SL-1,STMY,STR1
- 分子量
- 29 kDa
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