KNG1 Protein (His tag)
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- 抗原 See all KNG1 蛋白
- KNG1 (Kininogen 1 (KNG1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 人细胞
- 标记
- This KNG1 protein is labelled with His tag.
- 原理
- Recombinant Human Kininogen 1/KNG1 Protein (His Tag)
- 序列
- Gln19-Ser427
- 产品特性
- Recombinant Human Kininogen-1 is produced by our Mammalian expression system and the target gene encoding Gln19-Ser427 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product KNG1 蛋白
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Kininogen 1 (KNG1) (AA 19-380) protein (His tag)
KNG1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Kininogen 1 (KNG1) (AA 322-427) protein (GST tag)KNG1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (AA 1-427) protein (GST tag)KNG1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (Active) protein (His tag)KNG1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM Hac-NaAC, 150 mM NaCl, pH 4.0.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- KNG1 (Kininogen 1 (KNG1))
- 别名
- Kininogen 1/KNG1 (KNG1 产品)
- 别名
- BDK Protein, BK Protein, KNG Protein, Kng Protein, KNG2 Protein, fb64g01 Protein, wu:fb64g01 Protein, zgc:103569 Protein, kininogen Protein, bdk Protein, kng Protein, KNG1 Protein, IHRP Protein, KINKG Protein, KINKH Protein, Kng1 Protein, Kngk Protein, kininogen 1 Protein, kininogen 1 L homeolog Protein, inter-alpha-trypsin inhibitor heavy chain family member 4 Protein, kininogen 2-like 1 Protein, KNG1 Protein, Kng1 Protein, kng1 Protein, kng1.L Protein, ITIH4 Protein, Kng2l1 Protein
- 背景
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Background: Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn't involved in blood clotting.
Synonym: Kininogen-1, lpha-2-Thiol Proteinase Inhibitor, Fitzgerald Factor, High Molecular Weight Kininogen, HMWK, Williams-Fitzgerald-Flaujeac Factor, KNG1, BDK, KNG
- 分子量
- 46.9 kDa
- NCBI登录号
- NP_001095886
- 途径
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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