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IL-20 蛋白

IL20 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7318660
发货至: 中国
  • 抗原 See all IL-20 (IL20) 蛋白
    IL-20 (IL20) (Interleukin 20 (IL20))
    蛋白类型
    Recombinant
    宿主
    • 10
    • 5
    • 3
    • 1
    资源
    • 11
    • 5
    • 2
    大肠杆菌(E. Coli)
    原理
    Recombinant Human Interleukin-20/IL-20 Protein
    序列
    Leu25-Glu176
    产品特性
    Recombinant Human Interleukin-20 is produced by our E.coli expression system and the target gene encoding Leu25-Glu176 is expressed.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product IL20 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    IL-20 (IL20) (Interleukin 20 (IL20))
    别名
    Interleukin-20/IL-20 (IL20 产品)
    别名
    IL-20 Protein, IL10D Protein, ZCYTO10 Protein, Zcyto10 Protein, IL20 Protein, interleukin 20 Protein, IL20 Protein, Il20 Protein
    背景

    Background: Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28 % amino acid identity with IL-10 and 76 % amino acid identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 Rα and IL-20 Rβ. The second is composed of IL-22 R and IL-20 Rβ. Whereas the IL-22 R/IL-20 Rβ complex is shared with IL-24, the IL-20 Rα/IL-20 Rβ complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF-α and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.

    Synonym: Interleukin-20, IL-20, Cytokine Zcyto10, IL20, ZCYTO10

    分子量
    20.1 kDa
    UniProt
    Q9NYY1
    途径
    Protein targeting to Nucleus
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