IL36A/IL1F6 蛋白
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- 抗原 See all IL36A/IL1F6 (IL1F6) 蛋白
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human Interleukin-36 alpha/IL-36 alpha
- 序列
- Lys6-Phe158
- 产品特性
- Recombinant Human Interleukin-36 Alpha is produced by our E.coli expression system and the target gene encoding Lys6-Phe158 is expressed.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured in a cell proliferation assay using A-431 Human epithelial carcinoma cells. The ED50 for this effect is 12.0 ng/ml.
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Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (His tag)
IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-160) protein (His tag)IL1F6 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (GST tag)IL1F6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-61) protein (GST tag)IL1F6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interleukin 1 Family, Member 6 (IL1F6) protein (Myc-DYKDDDDK Tag)IL1F6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 0.02 % Tween 20, pH 8.0.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- 别名
- Interleukin-36 alpha/IL-36 alpha (IL1F6 产品)
- 别名
- Il1f6 Protein, Fil1 Protein, IL-1H1 Protein, IL1RP2 Protein, Il1f9 Protein, Il36a Protein, FIL1 Protein, FIL1(EPSILON) Protein, FIL1E Protein, IL-1F6 Protein, IL1(EPSILON) Protein, IL1F6 Protein, interleukin 36, alpha Protein, interleukin 1 family, member 6 (epsilon) Protein, interleukin 1 family, member 6 Protein, interleukin 36 alpha Protein, Il36a Protein, IL1F6 Protein, IL36A Protein, Il1f6 Protein
- 背景
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Background: Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
Synonym: Interleukin-36 Alpha, FIL1 Epsilon, Interleukin-1 Epsilon, IL-1 Epsilon, Interleukin-1 Family Member 6, IL-1F6, IL36A, FIL1E, IL1E, IL1F6
- 分子量
- 17.1 kDa
- UniProt
- Q9UHA7
- 途径
- Cancer Immune Checkpoints
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