Insulin Receptor Protein (INSR) (His tag)
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- 抗原 See all Insulin Receptor (INSR) 蛋白
- Insulin Receptor (INSR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Insulin Receptor protein is labelled with His tag.
- 原理
- Recombinant Human Insulin Receptor/INSR Protein (short isoform, His Tag)(Active)
- 序列
- Met 1-Lys 944
- 产品特性
- A DNA sequence encoding the human INSR isoform short (NP_001073285.1) extracellular domain (Met 1-Lys 944) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind human Insulin in a functional ELISA.
- Top Product
- Discover our top product INSR 蛋白
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Insulin Receptor (INSR) (AA 28-944) (Active) protein (His tag)
INSR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Insulin Receptor (INSR) (AA 1023-1298) protein (His-IF2DI Tag)INSR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Insulin Receptor (INSR) (AA 881-980) protein (GST tag)INSR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Insulin Receptor (INSR) (Active) protein (GST tag,His tag)INSR 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Insulin Receptor (INSR)
- 别名
- Insulin Receptor/INSR (INSR 产品)
- 别名
- CD220 Protein, HHF5 Protein, 4932439J01Rik Protein, D630014A15Rik Protein, IR Protein, IR-A Protein, IR-B Protein, 18402 Protein, CG18402 Protein, DIHR Protein, DILR Protein, DIR Protein, DIRH Protein, DIRbeta Protein, DInR Protein, DInr Protein, Dir-a Protein, Dir-b Protein, Dmel\\CG18402 Protein, INR Protein, INS Protein, Inr Protein, Inr-alpha Protein, Inr-beta Protein, InsR Protein, dINR Protein, dIR Protein, dIRH Protein, dInR Protein, dInr Protein, dInsR Protein, dinr Protein, dir Protein, er10 Protein, inr Protein, insulin/insulin-like growth factor receptor Protein, l(3)05545 Protein, l(3)93Dj Protein, l(3)er10 Protein, lnR Protein, ir-A Protein, CTK-1 Protein, ir Protein, INSR Protein, NV14476 Protein, cd220 Protein, hhf5 Protein, insulin receptor Protein, Insulin-like receptor Protein, insulin receptor L homeolog Protein, INSR Protein, Insr Protein, InR Protein, LOC100122567 Protein, LOC100451802 Protein, insr.L Protein
- 背景
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Background: INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
Synonym: CD220,HHF5,Insulin Receptor
- 分子量
- 106 (83+23) kDa
- NCBI登录号
- NP_001073285
- 途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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