TIM3 Protein (Fc Tag)
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- 抗原 See all TIM3 (TIM 3) 蛋白
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This TIM3 protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse TIM-3/HAVCR2 Protein (Fc Tag)(Active)
- 序列
- Arg20-Arg191
- 产品特性
- Recombinant Mouse TIM-3 is produced by our Mammalian expression system and the target gene encoding Arg20-Arg191 is expressed with a Fc tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Galectin 9-His(Cat: PKSH032470) at 2μg/ml(100 μl/well) can bind Mouse TIM-Fc. The ED50 of Mouse TIM-Fc is 4.053ug/ml .
- Top Product
- Discover our top product TIM 3 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 别名
- TIM-3/HAVCR2 (TIM 3 产品)
- 别名
- HAVCR2 Protein, MGC140131 Protein, HAVcr-2 Protein, KIM-3 Protein, TIM3 Protein, TIMD-3 Protein, TIMD3 Protein, Tim-3 Protein, TIM-3 Protein, Tim3 Protein, Timd3 Protein, tim3 Protein, hepatitis A virus cellular receptor 2 Protein, HAVCR2 Protein, Havcr2 Protein
- 物质类
- Virus
- 背景
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Background: T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
Synonym: Hepatitis A virus cellular receptor 2 homolog, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, Timd3
- 分子量
- 46.3 kDa
- UniProt
- Q8VIM0
- 途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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